Figure 8.

Single-channel currents elicited by 10 μM ACh from AChRs containing wild-type or mutant β subunits and complimentary α, δ, and ε subunits. Currents are shown filtered at 8 kHz with openings as upward deflections (a). Corresponding open- and closed-duration histograms (b and c) are shown fitted by the sum of exponentials with the following parameters. Wild-type: open durations, τ_o = 0.65 ms, number of events = 7681; closed durations, τ₁ = 0.45 ms, a₁ = 0.47, τ₂ = 2.5 ms, a₂ = 0.53. Mutant βdelEQE: open durations, τ_o = 0.99 ms, number of events = 2422; closed durations, τ₁ = 0.44 ms, a₁ = 0.39, τ₂ = 3.9 ms, a₂ = 0.61.