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Hypergammaglobulinemia is Tlr and Myd88 dependent. A and B, Total serum IgG was measured by ELISA in mice of the indicated genotypes and ages. C–F, Total serum IgG2a and IgG3 were measured by cytometric bead assay. Statistics were calculated by two-tailed Mann-Whitney U test. *p < 0.05; **p < 0.01; ***p < 0.001.
