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Kidney disease is ameliorated in Tlr7/9 and Myd88-deficient mice. Disease parameters were assessed in mice of the indicated genotypes and ages. A and B, Proteinuria. C and D, Severity of glomerulonephritis. E and F, The area of interstitial and perivascular infiltrates expressed as a percentage of the total kidney area. Data are represented as mean ± SEM. Statistics were calculated by two-tailed Mann-Whitney U test. *p < 0.05; **p < 0.01; ***p < 0.001.
