Table 2.

Convergent Functional Genomics(CFG) is one method of meta-analysis to identify genes which confer susceptibility to complex genetic disorders, including schizophrenia and bipolar disorder. The comparison of chronic LSD induced, differentially expressed genes to the top ranked genes implicated in schizophrenia and bipolar disorder reveals 6 genes common to both lists for schizophrenia, (Bdnf, Drd2, Grin2b, Prkca, Slc1a2, Tnik) and 5 genes in common for bipolar disorder (Bdnf, Gsk3b, Klf12, Ptprt, Syn3). This represents a significant (p=0.006) enrichment of 3.2 fold for schizophrenia genes and a nonsignificant (p=0.19) enrichment of 2.0 fold for bipolar disorder genes (chi-squared, Yates’ corrected, 2×2 contingency table).

Top Ranked Schizophrenia Genes (CFG score >4.0)(Ayalew et al., 2012)	Top Ranked Bipolar Genes (CFG score > 6.5)(Patel et al., 2010)
Expect: 4.45% (# of DE genes/Total genes: 755/16950)	Expect: 4.45% (# of DE genes/Total genes: 755/16950)
Found: 14.3% (6/42 genes)	Found: 8.9% (5/56 genes)
Relative Enrichment: 3.2 Fold	Relative Enrichment: 2.0 Fold
Odds Ratio: 3.6	Odds Ratio: 2.1
Significance: p=0.006	Significance: p=0.19