Figure 2.

Bile production in fatty livers perfused for 2 hours on the isolated perfusion rat liver apparatus after 6 hours of cold ischemia. Animals were pretreated with metalloporphyrins, or with Ad-HO-1 gene transfer, or left untreated. Bile production at 30-minute intervals throughout the reperfusion period was significantly higher in the CoPP/Ad-HO-1 groups (*P < 0.05) as compared with untreated, ZnPP-, or Ad-βGal–pretreated controls. These data represent the mean ± SE of 4–10 independent perfusions for each group. *P < 0.05 versus untreated/ZnPP-treated controls.