Figure 7.

Photomicrographs of representative liver isografts transplanted from obese Zucker donors into lean Zucker recipients and harvested at day 1. (a) Untreated group with significant edema and pallor around periportal hepatocytes and severe disruption of lobular architecture with zone 3 necrosis (arrow; Suzuki score = 3.33 ± 0.58); (b) CoPP- and (c) Ad-HO-1–treated groups with minimal pallor, no edema, and complete preservation of lobular architecture (score = 1.33 ± 0.70 and 1.5 ± 0.5, respectively). ×100, H&E stain; n = 2–3/group.