Table 2.
Chromosomal regions selected for sequencing based on haplotype sharing
| Eighteen shared haplotype regions | Chromosome | Location (hg18) | Location (hg19) | Affecteds sharing haplotype |
|---|---|---|---|---|
| 2p14-p12 |
2 |
65612029-76349401 |
65758525-76495893 |
6 of 6 |
| 2q23-q31 |
2 |
153638312-174296304 |
153930066-174588058 |
6 of 6 |
| 2q37 |
2 |
231435643-238617145 |
231727399-238952406 |
5 of 7 |
| 3q13 |
3 |
111604019-112685490 |
110121329-111202800 |
4 of 7 |
| 3q26-q27 |
3 |
174594938-185701563 |
173112244-184218869 |
4 of 7, 4 of 4 |
| 4q28-q31 |
4 |
137362554-141629142 |
137143104-141409692 |
6 of 6 |
| 7p21 |
7 |
7381742-11861952 |
7415217-11895427 |
4 of 4, 4 of 6 |
| 7p14 |
7 |
36090817-41521542 |
36124292-41555017 |
4 of 7 |
| 7q21-q31 |
7 |
90511244-107823133 |
90673308-108035897 |
5 of 8a |
| 7q35-36 |
7 |
142750349-151152511 |
143040227-151521578 |
4 of 6 |
| 12q21 |
12 |
76119990-77788028 |
77595859-79263897 |
5 of 7 |
| 12q21 |
12 |
79689788-87939487 |
81165657-89415356 |
5 of 8 |
| 14q11-q21 |
14 |
22912579-45661808 |
23842739-46592058 |
3 of 4, 6 of 6 |
| 14q32 |
14 |
92331535-103509782 |
93261782-104440029 |
4 of 4 |
| 15q12-q21 |
15 |
24339787-43759484 |
26788694-45972192 |
3 of 4, 4 of 6, 5 of 8 |
| 16q22-23 |
16 |
73415053-77780513 |
74857552-79223012 |
4 of 7, 5 of 6, 3 of 4 |
| 20p11-q13 |
20 |
25253250-41225971 |
25305250-41792557 |
4 of 7 |
| 20q13 | 20 | 49062886-57757418 | 49629479-58324023 | 5 of 6, 5 of 6 |
Where multiple numbers are given, multiple families shared overlapping haplotypes. aIndicates a family where a ninth affected individual was later shown not to share the same haplotype.