Table 4.
Distribution of G-CSF IR in non-cortical areas of the forebrain.
| Control |
AD |
|||||||
|---|---|---|---|---|---|---|---|---|
| Neuronal cell bodies |
Fibers |
Neuronal cell bodies |
Fibers |
|||||
| Density | Intensity | Density | Intensity | Density | Intensity | Density | Intensity | |
| Basal ganglia | ||||||||
| Claustrum | ++ | + | 0/++ | 0/+ | 0/+++ | 0/++ | 0/++ | 0/+ |
| Putamen | 0/+ | 0/+ | 0/++ | 0/+ | 0/+ | 0/+ | +/++ | + |
| Pallidum | ++ | ++ | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| Caudate nucleus | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| Basal nucleus of Meynert | ++ | + | 0 | 0 | ++/+++ | + | 0/++ | 0/+ |
| Hippocampus | ||||||||
| Dentate gyrus | 0/+ | 0/+ | 0 | 0 | 0/+ | 0/+ | 0/++ | 0/+ |
| Hilus | ++ | + | 0/++ | 0/+ | ++ | + | 0/++ | 0/+ |
| CA3 | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| CA2 | ++ | + | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| CA1 | 0/++ | 0/+ | 0 | 0 | 0 | 0 | 0/+ | 0/+ |
| Subiculum | ++ | +/++ | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| Entorhinal cortex | ++ | +/++ | 0/++ | 0/+ | 0/++ | 0/++ | 0/+ | 0/+ |
| Lateral geniculate nucleus | ++/+++ | ++ | 0/++ | 0/++ | ++/+++ | +/++ | 0/++ | 0/++ |
| Thalamus | ||||||||
| Anterior nucleus | ++ | + | 0/+ | 0/+ | 0/++ | 0/++ | 0/++ | 0/+ |
| Ventral anterior nucleus | ++ | +/++ | ++ | + | 0/+++ | 0/++ | 0/++ | 0/+ |
| Ventral lateral nucleus | ++/+++ | + | 0/++ | 0/+ | ++/+++ | +/++ | 0/++ | 0/+ |
| Dorsomedial nucleus | 0/+++ | 0/+ | 0/+ | 0/+ | 0/+++ | 0/++ | 0/++ | 0/+ |
| Subthalamic nucleus | ++ | + | 0/++ | 0/+ | 0/+++ | 0/++ | 0/++ | 0/+ |
| Pulvinar medial | ++/+++ | +/++ | 0/++ | 0/+ | 0/+++ | 0/+ | 0/++ | 0/+ |
| Lateral | ++ | + | 0/++ | 0/+ | ++ | + | +/++ | + |
| Hypothalamus | ||||||||
| Paraventricular nucleus | 0/++ | 0/+ | 0 | 0 | 0/++ | 0/+ | 0/+ | 0/+ |
| Supraoptic nucleus | 0 | 0 | 0 | 0 | 0/+++ | 0/++ | 0/+ | 0/+ |
| Dorsomedial nucleus | ++/+++ | + | 0 | 0 | +/++ | +/++ | 0/++ | 0/+ |
| Substantia nigra | 0 | 0 | 0/++ | 0/+ | 0 | 0 | 0/++ | 0/+ |
| Nucleus ruber | +++ | + | 0/++ | 0/+ | ++/+++ | +/++ | 0/++ | 0/+ |
| Mamillary bodies | 0/++ | 0/+ | 0/++ | 0/+ | 0/+/++ | 0/+ | 0/++ | 0/+ |
| Cerebellum | ||||||||
| Purkinje layer | 0/+ | 0/+ | − | − | 0/+ | 0/+ | − | − |
| Molecular layer | 0 | 0 | 0/++ | 0/+ | 0/+ | 0/+ | 0/++ | 0/+ |
| Granular layer | 0/++ | 0/++ | 0/++ | 0/+ | 0/+ | 0/++ | 0/++ | 0/+ |
| White matter | 0/+ | 0/++ | 0/++ | 0/+ | 0/+ | 0/+ | 0/++ | 0/+ |
| Dentate nucleus | ++ | + | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| Corpus amygdaloideum | ||||||||
| Lateral nucleus | 0/+++ | 0/++ | 0/++ | 0/+ | 0/+++ | 0/+ | 0/++ | 0/+ |
| Basomedial nucleus | 0/++ | 0/+ | 0/++ | 0/+ | +/++ | + | 0/++ | 0/+ |
| Basolateral nucleus | ++ | + | +/++ | + | ++ | + | 0/++ | 0/+ |
Density: 0: no immunoreactive structures, + up to 10%, ++ 10–50%, +++ more than 50%. Intensity: 0: no immunoreactivity, + faint, ++ moderate, +++ strong. The range of minimum and maximum staining between individual cases is given.