Table 5.
Distribution of G-CSF IR in the brainstem.
| Control |
AD |
|||||||
|---|---|---|---|---|---|---|---|---|
| Neuronal cell bodies |
Fibers |
Neuronal cell bodies |
Fibers |
|||||
| Density | Intensity | Density | Intensity | Density | Intensity | Density | Intensity | |
| Brain stem | ||||||||
| Oculomotor nucleus | +++ | +/++ | 0/++ | 0/+ | 0/+++ | 0/++ | 0/++ | 0/+ |
| Trochlear nucleus | ++/+++ | +/++ | 0/+++ | 0/++ | 0/+++ | 0/++ | 0/++ | 0/+ |
| Pontine nuclei | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/++ | 0/++ | 0/+ |
| Locus caeruleus | 0 | 0 | 0 | 0 | 0 | 0 | 0/++ | 0/+ |
| Mesencephalic nucleus | 0/++ | 0/++ | 0/++ | 0/+ | 0/++ | 0/+ | 0/++ | 0/+ |
| Dorsal raphe nucleus | ++ | +/++ | 0/++ | 0/+ | 0/+++ | 0/++ | 0/+++ | 0/+ |
| Facial motor nucleus | +++ | +/++ | ++ | + | 0/+++ | 0/++ | 0/++ | 0/+ |
| Superior salivatory nucleus | 0/+++ | 0/+ | 0 | 0 | 0/++ | 0/++ | 0 | 0 |
| Abducens nucleus | ++/+++ | +/++ | 0/++ | 0/+ | ++ | + | +/++ | + |
| Superior olivary nucleus | 0 | 0 | ++ | + | 0 | 0 | 0 | 0 |
| Inferior olivary nucleus | ++/+++ | +/++ | ++ | + | ++/+++ | + | +/++ | + |
| Accessory olivary nucleus | ++/+++ | +/++ | ++ | + | ++/+++ | +/++ | 0/+ | 0/+ |
| Arcuate nucleus | 0/+++ | 0/+ | 0/+++ | 0/+ | 0/++ | 0/+ | +/++ | + |
| Nucleus ambiguus | 0/+++ | 0/+ | 0/++ | 0/+ | ++ | + | 0 | 0 |
| Nucleus of solitary tract | ++/+++ | + | ++ | + | 0/+++ | 0/+ | 0/++ | 0/+ |
| Spinal tigeminal nucleus | ++ | + | 0/++ | 0/++ | 0/++ | 0/+ | 0/++ | 0/+ |
| Trigeminal motor nucleus | ++/+++ | + | 0 | 0 | 0/+++ | 0/+ | 0/++ | 0/+ |
| Hypoglossal nucleus | ++/+++ | +/++ | 0/++ | 0/+ | ++/+++ | +/++ | 0/++ | 0/+ |
| Dorsal motor nucleus of vagus | ++ | +/++ | 0/+++ | 0/+ | 0/++ | 0/++ | 0/++ | 0/+ |
| Inferior vestibular nucleus | ++/+++ | +/++ | ++ | + | ++ | + | 0/++ | 0/+ |
| Medial vestibular nucleus | ++ | +/++ | 0/++ | 0/+ | 0/++ | 0/++ | 0/++ | 0/+ |
| Gracile nucleus | 0/+++ | 0/++ | ++ | + | 0/++ | 0/+ | 0/++ | 0/++ |
| Cuneate nucleus | 0/++ | 0/++ | 0/+++ | 0/+ | 0/++ | 0/+ | +/++ | + |
Density: 0: no immunoreactive structures, + up to 10%, ++ 10–50%, +++ more than 50%. Intensity: 0: no immunoreactivity, + faint, ++ moderate, +++ strong. The range of minimum and maximum staining between individual cases is given.