Table 2.

Quantitative metrics of atrophy by region within primary sample of participants.

	Region	Mean thickness and SD (mm)						Percent atrophy		Ratio
		YC (N = 142)		OC (N = 87)		AD (N = 28)		OCvsYC	ADvsYC	ADvsOC
Aging	Calcarine	1.84O,A	0.13	1.48Y,A	0.14	1.38Y,O	0.20	19.6	25.0	1.3
	Caudal insula	2.34O,A	0.15	1.93Y	0.16	1.86Y	0.21	17.6	20.4	1.2
	Cuneus	2.01O,A	0.1	1.70Y,A	0.12	1.63Y,O	0.12	15.3	19.1	1.2
	Caudal fusiform	2.01O,A	0.12	1.76Y	0.16	1.71Y	0.18	12.3	14.8	1.2
	Dorsomedial frontal	2.99O,A	0.16	2.65Y	0.16	2.58Y	0.20	11.6	13.8	1.2
	Lateral occipital	2.08O,A	0.11	1.85Y,A	0.12	1.79Y,O	0.19	11.3	14.1	1.2
	Precentral	2.55O,A	0.11	2.27Y,A	0.14	2.20Y,O	0.18	11.0	13.7	1.2
	Inferior frontal	2.70O,A	0.15	2.43Y,A	0.13	2.34Y,O	0.19	10.0	13.2	1.3
AD	Medial temporal	2.99O,A	0.31	2.85Y,A	0.35	2.51Y,O	0.32	4.8	16.1	3.4
	Inferior temporal	2.77A	0.20	2.73A	0.26	2.36Y,O	0.23	1.6	14.8	9.4
	Temporal pole	2.76O,A	0.22	2.57Y,A	0.23	2.39Y,O	0.20	6.9	13.5	1.9
	Superior parietal	2.10O,A	0.138	2.00Y,A	0.13	1.87Y,O	0.14	4.7	11.2	2.4
	Precuneus	2.34O,A	0.19	2.17Y,A	0.14	2.03Y,O	0.19	7.5	13.3	1.8
Aging and AD overlap	Angular	2.58O,A	0.15	2.33Y,A	0.16	2.09Y,O	0.24	9.6	19.1	2.0
	Supramarginal	2.65O,A	0.17	2.41Y,A	0.18	2.18Y,O	0.20	9.1	18.0	2.0
	Superior frontal	2.85O,A	0.18	2.57Y,A	0.18	2.34Y,O	0.22	9.8	17.8	1.8
	Middle frontal	2.36O,A	0.13	2.21Y,A	0.12	2.01Y,O	0.15	6.2	14.6	2.4
Mean: entire cortex		2.34O,A	0.08	2.20Y,A	0.12	2.05Y,O	0.11	6.2	12.6	2.0
Mean: aging-specific ROIs		2.31O,A	0.13	2.01Y,A	0.14	1.94Y,O	0.18	13.3	16.4	1.2
Mean: AD-specific ROIs		2.59O,A	0.21	2.46Y,A	0.22	2.12Y,O	0.26	5.0	18.3	3.6
Mean: overlap ROIs		2.61O,A	0.16	2.38Y,A	0.16	2.11Y,O	0.21	8.8	19.3	2.2

YC = young controls; OC = older controls, AD = Alzheimer's disease patients.

^Y,O,Ap < .05 different than YC, OC, or AD.