Table 1.
Baseline Characteristics of Pregnancies Complicated by a Fetus With an Isolated Major Structural Anomaly Compared to a Pregnancies Without Major Fetal Anomalies
| Isolated Major Anomaly Present (n=873) |
Major Anomaly Absent (n=64,165) |
P | |
|---|---|---|---|
| Maternal age | |||
| AMA (>34 yrs) | 177 (20.3) | 18,516 (28.9) | <0.01 |
| Race | |||
| Black | 176 (20.2) | 14,732 (22.9) | <0.01 |
| White | 598 (68.5) | 39,305 (61.3) | |
| Other | 99 (11.3) | 10,128 (15.8) | |
| Nulliparous | 369 (42.3) | 24,742 (38.6) | 0.03 |
| BMI | |||
| BMI ≥30 | 142 (16.3) | 12,695 (19.8) | 0.01 |
| Diabetes | |||
| Pregestational DM | 24 (2.7) | 1189 (1.9) | 0.05 |
| Gestational DMa | 25 (2.9) | 3250 (5.2) | <0.01 |
| Hypertension | |||
| Chronic hypertension | 12 (1.4) | 1558 (2.4) | 0.04 |
| Preeclampsia or gestationalb hypertension | 67 (7.9) | 5085 (8.1) | 0.77 |
| Amniocentesis performed during the pregnancy | 192 (22.0) | 7311 (11.4) | <0.01 |
| Median gestational age at delivery in weeks (IQR) | 38.1 (36.1–39.3) | 39.1 (38.1–40.0) | <0.01 |
| Median birthweight in grams (IQR) | 2931 (2260–3433) | 3348 (2951–3689) | <0.01 |
| Birthweight <10%ile | 213 (24.4) | 7376 (11.5) | <0.01 |
| History of prior stillbirth | 14 (1.6) | 1454 (2.3) | 0.19 |
IQR, interquartile range
a
Denominators for anomalies group (n=852) and non-anomolous group (n=62,449) due to missing data
b
Denominators for anomalies group (n=852) and nonanomolous group (n=62,446) due to missing data.