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. 2014 May 20;2(5):e12006. doi: 10.14814/phy2.12006

Figure 2.

Figure 2.

(A) ELISA for TNFα was performed from serum 24 h the initiation of femoral artery ligation. There is significant elevation in serum TNFα in all surgically manipulated groups compared to unligated animals (*P <0.001, ANOVA; N =4/group). (B) ELISA for IL‐6 was performed 4 h, 24 h, and 1 week after femoral artery ligation. All mice had significantly elevated IL‐6 levels 4 h after injury when compared to unligated animals (*P <0.05, ANOVA; N =4–7/group). Twenty‐four hours after injury, MyD88 KO mice demonstrated significantly less IL‐6 in serum than their littermate controls (**P <0.05, t‐test; N =4/group). Only TRIF KO mice had detectable IL‐6 in serum (***P =0.002, ANOVA, N =4–7/group) 1 week after injury.