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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Thromb Haemost. 2014 May;12(5):680–689. doi: 10.1111/jth.12534

Figure 3. Intravital microscopy shows both γA/γA and γA/γ’ isoforms are incorporated into murine thrombi.

Figure 3

Venules were visualized in the cremaster muscle of mice infused with HBS (control) or AlexaFluor 594-labeled anti-platelet (anti-GPIX) antibody, AlexaFluor 647-labeled anti-fibrin antibody, and purified γA/γA or γA/γ’ directly labeled with AlexaFluor 488. Thrombosis was triggered via laser injury. Flow is indicated by white arrows. Colors are: platelets (red), fibrin(ogen) (green), and fibrin (blue). In the merged image, colors are: platelets plus fibrin(ogen) (pink), platelets plus fibrin (purple), and fibrin(ogen) plus fibrin (teal). Images show representative thrombi from 3–4 mice with 14–20 injuries total.