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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Thromb Haemost. 2014 May;12(5):680–689. doi: 10.1111/jth.12534

Figure 4. γA/ γA fibrinogen shortens the time to vessel occlusion after arterial injury, but γA/γ’ does not.

Figure 4

Mice were infused with HBS, unfractionated (UF), γA/γA, or γA/γ’ fibrinogen to 170%, total fibrinogen. Thrombosis was induced by FeCl3 application to the carotid artery and TTO was determined by Doppler flow probe. In vessels that did not occlude, the TTO was recorded as 40 minutes. A) Each point represents a separate mouse. Lines indicate median values, *p<0.05 versus HBS. B) Percent of mice occluded at 7.25 minutes (the median TTO of HBS-infused mice), using the data from (A); 100%, 86%, and 50% of UF-, γA/γA-, and γA/γ’-infused mice, respectively, had occluded vessels at this time.