. Author manuscript; available in PMC: 2015 May 1.

Published in final edited form as: J Thromb Haemost. 2014 May;12(5):680–689. doi: 10.1111/jth.12534

Table 3.

Effect of Fibrinogen Isoforms on Mouse Plasma Clotting

Total Fibrinogen (mg/mL [%])	Fibrinogen/Buffer Infused	Human γA/γ’ Final (mg/mL)	Human γ’-to- Total Ratio (%)	Lagtime (minutes)	Change in Turbidity (OD)	Vmax (mOD/min)
2.4 (100%)	HBS	0	0	4.0±0.3	0.111±0.003	28.0±2.5
3.2 (135%)	γA/γA	0	0	3.5±0.3	0.222±0.016^*	73.3±8.9^*
3.2 (135%)	γA/γ’	0.8	25.9	4.0±0.4	0.184±0.023^*	47.4±5.0^*,^#
4.1 (170%)	γA/γA	0	0	4.0±0.3	0.350±0.015^*	126.7±4.6^*
4.1 (170%)	γA/γ’	1.7	41.2	4.1±0.2	0.265±0.012^*,^#	66.2±5.2^*,^#

Mean±SD,

P<0.03 versus HBS;

P<0.02 versus γA/γA (at same total fibrinogen)