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Barrier disruption results in activation of A- and N-SMase in hairless mice (hr–/–). Immediately (0 hours), 1 hour, and 3 hours after barrier disruption, skin samples were obtained, the epidermis was isolated, and SMases were determined in epidermal homogenates by in vitro mixed micelle enzyme assays using radiolabeled sphingomyelin as substrate. (a) A-SMase (*P < 0.05, n = 6). (b) N-SMase (*P < 0.005, n = 8).
