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. 1999 Dec 15;104(12):1761–1770. doi: 10.1172/JCI5307

Figure 6.

Figure 6

Topical application of imipramine results in delay of permeability barrier repair and reduction of stimulated A-SMase activity. Barrier disruption in hairless mice and application of imipramine (30 μL, 1% wt/wt) was performed as described in Figure 1. (a) Recovery in TEWL was determined at different time points after treatment (*P < 0.05, n = 5). (b) A-SMase (*P < 0.01, n = 6) and (c) N-SMase (*P < 0.025, n = 6) activities were determined at 1 hour after barrier disruption in the absence (open bars) and presence (filled bars) of imipramine.