Table 3.

Criteria for Response/Failure and Change of Therapy

Time (mo)	Imatinib	Second generation TKI
3–6	MCyR; BCR-ABL transcript levels≤10% (IS)	CCyR; BCR-ABL transcript levels≤1% (IS)
12	CCyR; BCR-ABL transcript levels≤1% (IS)	CCyR; BCR-ABL transcript levels≤1% (IS)
Later	CCyR; BCR-ABL transcript levels≤1% (IS)	CCyR; BCR-ABL transcript levels≤1% (IS)

Note. MCyR roughly = BCR-ABL≤10% (IS); CCyR roughly = BCR-ABL≤1% (IS).

Abbreviations: MCyR, major cytogenetic response (Ph≤35%); CCyR, complete cytogenetic response (Ph=0%); IS, International Scale.