Table 2. Current Status and Reasons for Removal from Protocol Treatment.
| Initial Registration | Crossover Treatment with Vandetanib following Progression on Docetaxel Arm | |||
|---|---|---|---|---|
| Treatment Result | TOTAL | Docetaxel | Docetaxel + Vandetanib | Vandetanib |
| NUMBER ON PROTOCOL TREATMENT | 1 | 1 | 0 | 0 |
| NUMBER OFF PROTOCOL TREATMENT | 128 | 65 | 63 | 33 |
| REASON OFF TREATMENT | ||||
| Adverse events or side effects | 22 | 7 | 15 | 1 |
| Refusal unrelated to adverse event | 13 | 8 | 5 | 1 |
| Progression/relapse | 82 | 47 | 35 | 30 |
| Death | 0 | 0 | 0 | 0 |
| Other-not protocol specified | 11 | 3 | 8 | 1 |
| MAJOR PROTOCOL DEVIATIONS | 4 | 2 | 2 | 0 |