Figure 1. Domain structure of the three subunits of the HSV helicase/primase (UL5, UL8 and UL52).
The conserved motifs of UL5 are shown as seven black boxes shared within superfamily 1 members. Two conserved UL52 domains are shown: the LVFDID catalytic domain (608 – 630) and putative zinc binding domain at the C-terminus (residues 998 – 1028). UL8 is a 751 aa protein with no known functional motifs.