A. UL5 amino acid substitutions in HSV-1 mutants resistant to HPIs. Several HPI-resistant mutations have been mapped to the UL5 gene. The amino acid substitutions are shown for mutants resistant to T157602, BAY 57-1293, BILS 22BS or ASP2151 [104,107,108,119,122]. B. UL52 Amino acid substitutions in HSV mutants resistant to HPIs. Arg367His was found in a ASP2151-resistant mutant [122] and A899T was found in a BAY 57-1293-resistant mutant [121]