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. 1999 Dec 15;104(12):1751–1759. doi: 10.1172/JCI7310

Figure 1.

Figure 1

Bone marrow HPC, macrophages and B cells from SHIP-deficient mice have enhanced chemotaxis to SDF-1. (a) Bone marrow cells were examined for their ability to transmigrate from the upper chamber toward SDF-1 at indicated concentrations in the lower chamber. After chemotaxis, myeloid progenitors in input and the lower chamber were assayed by methylcellulose colony assay. HPC (CFU-GM) migration was normalized for the number of input colony-forming HPCs to obtain HPC migration rate (% of input ± SD). Chemotaxis of CD11b/Mac-1+ F4/80+ bone marrow macrophages (b) and bone marrow B220+ B cells (c) in response to SDF-1. Data are expressed as the mean (± SD) of percent cell migration obtained from triplicated points. Results are each 1 representative of 5 independent experiments with consistent results. *Significant differences were observed between the wild-type and SHIP-deficient cells (P < 0.03).