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. 1999 Dec 15;104(12):1751–1759. doi: 10.1172/JCI7310

Figure 5.

Figure 5

SHIP-deficient HPCs are resistant to the suppressive activity of chemokines but are sensitive to that of TNF-α and IFN-γ. Bone marrow cells from wild-type and SHIP-deficient mice were plated into methylcellulose culture medium (see Methods) in the presence of PBS, 100 ng/mL chemokines, or 10 ng/mL TNF-α and IFN-γ. Colony formation of HPCs (CFU-GM, BFU-E, CFUGEMM) was assessed after 7 days of incubation. Results shown are the average (mean ± SD) for 4 separate experiments using wild-type cells and 5 separate experiments using SHIP-deficient cells.