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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell. 2014 May 22;157(6):1393–1404. doi: 10.1016/j.cell.2014.03.064

Figure 4. SVmab1 inhibits hNaV1.7 in a subtype-specific manner in HEK293 cells.

Figure 4

(A) Current-voltage relationships of the seven different NaV channel subtypes in the absence (○) and presence (●) of 10 µM SVmab1. Voltage steps were applied from −80 to +60 mV taken in 10-mV increments for 30 ms at a holding potential of −120 mV. (B) Concentration–response curves of the NaV channel subtypes (IC50 = 30.9 ± 1.9 nM for NaV1.7, 6.3 ± 2.2 µM for NaV1.6, and >5 µM for NaV1.1, 1.2, 1.3, 1.4, 1.5, and 1.8). Sodium currents were elicited by stepping to −10 mV from a holding potential of −120 mV for a duration of 30 ms at a frequency of 2 Hz. Data are shown as means ± SEM. (n = 6–10/group).