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. Author manuscript; available in PMC: 2015 Jun 5.

Published in final edited form as: Cell. 2014 May 22;157(6):1393–1404. doi: 10.1016/j.cell.2014.03.064

Table 1.

	Maximum inhibition (%)	IC₅₀ (µM)^*	Selectivity for Na_V1.7
Na_V1.1	20.7 ± 9.2	6.3 ± 4.4	861.5
Na_V1.2	18.7 ± 9.9	9.0 ± 9.8	1362.3
Na_V1.3	16.2 ± 7.6	8.7 ± 4.8	1520.1
Na_V1.4	21.5 ± 9.4	7.9 ± 6.6	1040.1
Na_V1.5	19.1 ± 7.5	5.6 ± 7.7	829.9
Na_V1.6	44.2 ± 5.9	6.3 ± 2.2	403.5
Na_V1.7	86.9 ± 2.9	0.0307 ± 0.0019	1
Na_V1.8	22.1 ± 7.8	5.2 ± 6.9	666.1

Selectivity = (Max_Nav1.7/Max_Nav1.x) × (IC_50Nav1.x/IC_50Nav1.7)

^*

IC₅₀ values were measured at 2 Hz and shown as means ± SEM, n= 6–10 per each subtype