Figure 8.

Enhanced effect of cyclosporine to prolong allograft survival in AT_1A receptor-deficient recipients. Heterotropic cardiac allografts were placed in Agtr1a^+/+ (filled symbols) and Agtr1a^–/– (open symbols) mice. Recipient animals received cyclosporine for 7 days at 2 doses, 10 mg/kg per day (diamonds) and 20 mg/kg per day (triangles). These subtherapeutic doses of cyclosporine had no significant effect on graft survival in the Agtr1a^+/+ mice. Cyclosporine caused a modest but significant prolongation of survival in the Agtr1a^–/– animals (P < 0.014 versus wild-type).