Overall Survival of all Richter syndrome patients according to the RS score
*: RS score as described by Tsimberidou et al. Each of the following characteristics at the time of diagnosis of RS gets one point: ECOG performance status of 2–4, LDH >1.5× normal, PLT <100, Tumour size >5 cm and >1 prior therapy for CLL. Patients are then assigned to one of three risk groups based on their calculated RS score: 0 or 1, low risk; 2 or 3, intermediate risk; 4 or 5, high risk.