Table 2.
BPA exposure mainly induced the down-regulation of a set of micro RNAs in various pathways in the penile shaft.
| Micro RNA | BPA-L | BPA-H | CEV* | EMT | Fibrosis | Inflammation |
|---|---|---|---|---|---|---|
| Up-regulated | ||||||
| 568 | 1.13 | 1.74 | 446 | − | − | − |
| 451-5p | 1.83 | 1.41 | 869 | − | + | + |
| Down-regulated | ||||||
| 664-1-5p | 0.71 | 0.55 | 2081 | − | − | − |
| 296-3p | 1.07 | 0.53 | 2321 | + | +++ | ++ |
| 377-3p | 0.53 | 0.52 | 1556 | + | + | − |
| 1224 | 0.58 | 0.50 | 751 | − | − | + |
| 665 | 0.58 | 0.50 | 751 | − | − | − |
| 182 | 0.38 | 0.47 | 470 | + | + | + |
| 672-5p | 0.38 | 0.47 | 464 | − | − | − |
| 483-5p | 0.93 | 0.46 | 1333 | + | − | + |
| 1306-3p | 1.48 | 0.44 | 683 | − | − | − |
| 210-3p | 1.46 | 0.42 | 683 | + | + | + |
| 3584 | 0.69 | 0.39 | 1064 | − | − | − |
| 494-3p | 0.68 | 0.36 | 1450 | + | + | + |
| 206-3p | 1.48 | 0.36 | 1595 | − | + | + |
| 200c | 0.92 | 0.35 | 1478 | ++++ | ++ | ++ |
| 328a | 0.54 | 0.32 | 1818 | − | − | + |
| 347 | 0.34 | 0.31 | 448 | + | − | − |
| 200b | 0.93 | 0.29 | 2174 | ++++ | ++ | ++ |
| 6216 | 0.35 | 0.28 | 994 | − | − | − |
| 6215 | 0.43 | 0.26 | 968 | − | − | − |
| 429 | 1.11 | 0.24 | 652 | + | − | + |
| 200a | 1.38 | 0.19 | 963 | ++++ | ++ | ++ |
| 205 | 0.87 | 0.19 | 7027 | +++ | + | + |
| 203a | 0.21 | 0.13 | 2309 | ++ | − | ++ |
The detection of miRs was performed in RNA extracted from pools of 3 penises. Among functionally relevant genes only those with changes >1.4 or <0.55 fold after high dose exposure (and having the same direction of change at the low dose) were entered. BPA-H/C: ratio of gene expression in the high dose of BPA (1 mg/kg/day) versus control RNA; BPA-L/C: similar but with the low dose (0.1 mg/kg/day); CEV: control expression value. The relationship to inflammation, fibrosis and EMT is indicated by + through ++++, according to the number of citations in Pubmed retrieved by linking as key words the miR to the pathological process.