Figure 3.

Exogenous IL-2 does not restore the suppressed T-cell response. AChR-specific lymphocyte proliferation of rats treated by Hα1-205 or OVA at the acute phase of EAMG was measured before (a) and after a 5-day culture in the absence (b) or presence (c) of rat rIL-2. Results are expressed as mean stimulation index (counts per minute incorporated by stimulated cells per counts per minute incorporated by unstimulated cells). Biologic activity of rIL-2 was verified by the proliferative response of the CTLL cell line. Representative of 3 independent experiments. *P < 0.005.