Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Mol Cell Biochem. 2014 Jan;385(0):145–157. doi: 10.1007/s11010-013-1823-3

Fig. 1.

Fig. 1

A Smurf1 and Jab1 regulate BMP pathway by targeting Smads for degradation. BMP-2-induces receptor-mediated phosphorylation of the receptor-regulated Smad proteins 1/5 (R-Smads). Activated Smads1/5 bind the common Smad (Co-Smad), Smad 4, translocate to nucleus, and initiate transcription of various osteogenic genes. R-Smads and Co-Smad are targeted for degradation by Smurf1 and Jab1, respectively. B LMP-1 protein sequence contains one PDZ domain and three LIM domains. There are specific sequence motifs that interact with Smurf1 and Jab1 within its unique central osteogenic domain