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Smad1/5 and Smad4 are targeted by Smurf1 and Jab1 for degradation, respectively. LMP-1 interactions with Smurf1 and Jab1 are necessary to be fully functional in its BMP-potentiating activity by rescuing Smads1/5 and Smad4 from degradation. LMP-1 may also increase cellular responsiveness to TGF-β by rescuing Smad4 from degradation
