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. 2014 Jun 26;2014:571302. doi: 10.1155/2014/571302

Figure 2.

Figure 2

Decreased number of Tregs in patients with ITP. (a) Representative dot plots of Tregs (CD25+Foxp3+, gated on CD4+ cells) in one healthy subject and one ITP patient before and after first-line therapies. (b) Decreased frequency of Tregs can be improved by first-line therapies in ITP patients. (c) The expression of FOXP3 mRNA was also decreased in ITP patients. (d) The deficiency in the number of Tregs was corrected by first-line therapies in R patients, but not in NR patients. *P < 0.05; **P < 0.01; ***P < 0.001.