Table 4.

Gene interactions between SNPs in different folate pathway genes^‡

A. NHW
Gene A	Marker A	Gene B	Marker B	P-value
BHMT	rs567754	TYMS	rs495139	0.006
BHMT2	rs476620	BHMT	rs585800	0.005
BHMT2	rs2253262	CBS	rs2851391	0.010
FOLR1	rs11235462	CBS	rs1801181	0.008
FOLR1	rs1540087	CBS	rs234783	0.009
FOLR1	rs11235462	MTHFD1	rs2236224	0.008
FOLR1	rs1540087	MTHFS	rs2586179	0.0004
FOLR1	rs1540087	SLC19A1	rs4819130	0.007
FOLR2	rs2298444	CBS	rs234714	0.001
FOLR2	rs2276048	CBS	rs234714	0.007
FOLR2	rs2298444	MTHFS	rs2115540	0.007
MTHFD1	rs1256142	CBS	rs12329790	0.005
MTHFD1	rs2236224	CBS	rs12329790	0.009
MTHFD1	rs34616731	SLC19A1	rs3788205	0.001
MTHFD1	rs1256146	SLC19A1	rs3788205	0.007
MTHFD2	rs7587117	MTHFS	rs2586179	0.002
MTHFD2	rs7587117	MTHFS	rs2562744	0.002
MTHFD2	rs7571842	MTHFS	rs2562744	0.003
MTHFD2	rs7571842	MTHFS	rs2586179	0.004
MTHFD2	rs7587117	MTRR	rs162029	0.006
MTHFD2	rs828858	MTRR	rs162029	0.010
MTHFR	rs1889292	SLC19A1	rs1051266	0.003
MTHFR	rs1889292	SLC19A1	rs3788205	0.009
MTHFR	rs1476413	SLC19A1	rs4819130	0.009
MTHFS	rs2586179	TYMS	rs2853741	0.007
MTRR	rs2303080	MTHFD1	rs34616731	0.002
MTRR	rs2303080	MTHFD1	rs1256146	0.009
NOS3	rs1800779	CBS	rs1051319	0.003
NOS3	rs1800779	FOLR2	rs2276048	0.007
NOS3	rs2373929	MTHFD1	rs1076991	0.002
NOS3	rs891512	MTHFS	rs2586179	0.007
NOS3	rs1800779	MTHFS	rs2562744	0.009

B. Hispanic
Gene A	Marker A	Gene B	Marker b	p-value
BHMT	rs645112	MTHFD1	rs1256146	0.010
BHMT2	rs626105	CBS	rs1051319	0.008
BHMT2	rs476620	CBS	rs1801181	0.010
BHMT2	rs2253262	MTHFD1	rs2236225	0.009
BHMT2	rs682985	SLC19A1	rs2297291	0.005
BHMT2	rs1422086	SLC19A1	rs2297291	0.009
CBS	rs234783	SLC19A1	rs4819130	0.008
CBS	rs2851391	SLC19A1	rs3788190	0.009
MTHFD1	rs2236222	SLC19A1	rs2297291	0.002
MTHFD1	rs1885031	SLC19A1	rs2297291	0.008
MTHFD1	rs1076991	TYMS	rs502396	0.004
MTHFD1	rs1076991	TYMS	rs2853532	0.010
MTHFR	rs1889292	BHMT2	rs2253262	0.008
MTHFR	rs4846052	CBS	rs2851391	0.005
MTHFR	rs3737964	CBS	rs234784	0.009
MTHFR	rs1476413	FOLR1	rs11235462	0.001
MTHFR	rs3737964	FOLR1	rs11235462	0.004
MTHFR	rs1889292	FOLR2	rs2276048	0.006
MTHFR	rs1476413	FOLR2	rs2276048	0.010
MTHFR	rs1476413	SLC19A1	rs10483080	0.006
MTHFR	rs1801131	SLC19A1	rs10483080	0.009
MTR	rs12354209	MTHFD2	rs7587117	0.001
MTR	rs1770449	MTHFD2	rs7587117	0.003
MTR	rs1266164	MTHFD2	rs7587117	0.004
MTR	rs1806505	MTHFD2	rs7587117	0.005
MTR	rs1266164	MTHFD2	rs828858	0.005
MTR	rs6668344	MTHFD2	rs828858	0.007
MTR	rs1770449	MTHFD2	rs828858	0.008
MTR	rs4077829	MTHFD2	rs828858	0.009
MTR	rs12354209	MTHFD2	rs828858	0.010
MTRR	rs162029	CBS	rs234783	0.003
NOS3	rs3918211	CBS	rs1051319	0.007
NOS3	rs2373929	SLC19A1	rs12483377	0.010
TYMS	rs1001761	CBS	rs234785	0.008

^‡only p-values ≤ 0.01 shown, NHW = nonHispanic white group