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. 2014 Jul 15;9(7):e100442. doi: 10.1371/journal.pone.0100442

Table 3. Mutations (including missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) at different AJCC staging.

Genes Number of samples with mutations (Mutation frequency in 238 samples) Number of stage 1A samples with mutations (Mutation frequency in 26 samples) Number of stage 1B samples with mutations (Mutation frequency in 34 samples) Number of stage 2 samples with mutations (Mutation frequency in 49 samples) Number of stage 3A samples with mutations (Mutation frequency in 79 samples) Number of stage 3B samples with mutations (Mutation frequency in 29 samples) Number of stage 4 samples with mutations (Mutation frequency in 21 samples)
ABL1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
AKT1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
ALK 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
APC 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
ATM 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
BRAF 2(0.8%) 0(0.0%) 0(0.0%) 1(2.0%) 0(0.0%) 1(3.4%) 0(0.0%)
CDH1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
CDKN2A 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
CSF1R 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
CTNNB1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
EGFR 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
ERBB2 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
ERBB4 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
FBXW7 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
FGFR1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
FGFR2 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
FGFR3 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
FLT3 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
GNAS 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
HNF1A 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
HRAS 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
IDH1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
JAK3 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
KDR 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
KIT 2(0.8%) 0(0.0%) 0(0.0%) 1(2.0%) 1(1.3%) 0(0.0%) 0(0.0%)
KRAS 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
MET 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
MLH1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
MPL 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
NOTCH1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
NPM1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
NRAS 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
PDGFRA 1(0.4%) 0(0.0%) 0(0.0%) 1(2.0%) 0(0.0%) 0(0.0%) 0(0.0%)
PIK3CA 2(0.8%) 0(0.0%) 1(2.9%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
PTEN 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 1(1.3%) 0(0.0%) 0(0.0%)
PTPN11 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
RB1 1(0.4%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 1(4.8%)
RET 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
SMAD4 2(0.8%) 0(0.0%) 0(0.0%) 1(2.0%) 1(1.3%) 0(0.0%) 0(0.0%)
SMARCB1 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
SMO 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
SRC 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
STK11 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)
TP53 23(9.7%) 3(11.5%) 3(8.8%) 7(14.3%) 8(10.1%) 0(0.0%) 2(9.5%)
VHL 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%) 0(0.0%)