Table 4. Mutations (including missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) of different differentiation types of GAs.

Genes	Number of samples with mutations in 238 samples (Mutation frequency)	Number of low differentiation samples with mutations (Mutation frequency in 125 samples)	Number of middle-low differentiation samples with mutations (Mutation frequency in 14 samples)	Number of middle differentiation samples with mutations (Mutation frequency in 84 samples)	Number of unknown samples with mutations (Mutation frequency in 15 unknown samples)
ABL1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
AKT1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ALK	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
APC	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
ATM	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
BRAF	2(0.8%)	1(0.8%)	0(0.0%)	1(1.2%)	0(0.0%)
CDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CDKN2A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CSF1R	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CTNNB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
EGFR	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ERBB2	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
ERBB4	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FBXW7	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR2	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FLT3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
GNAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HNF1A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
IDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
JAK3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KDR	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KIT	2(0.8%)	2(1.6%)	0(0.0%)	0(0.0%)	0(0.0%)
KRAS	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
MET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MLH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MPL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NOTCH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NPM1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
PDGFRA	1(0.4%)	0(0.0%)	0(0.0%)	1(1.2%)	0(0.0%)
PIK3CA	2(0.8%)	0(0.0%)	1(7.1%)	0(0.0%)	1(6.7%)
PTEN	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
PTPN11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
RB1	1(0.4%)	1(0.8%)	0(0.0%)	0(0.0%)	0(0.0%)
RET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMAD4	2(0.8%)	1(0.8%)	0(0.0%)	1(1.2%)	0(0.0%)
SMARCB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMO	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SRC	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
STK11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
TP53	23(9.7%)	10(8.0%)	0(0.0%)	10(11.9%)	3(20.0%)
VHL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)