Table 1.
Clinicopathological data with univariate and multivariable analysis for disease specific survival within the CRC cohort
| Clinicopathological parameters | Patient number (n) |
Univariate |
Multivariable |
||||||
|---|---|---|---|---|---|---|---|---|---|
|
HR |
95% CI |
P value |
HR |
95% CI |
P value |
||||
| Lower | Upper | Lower | Upper | ||||||
|
Dukes |
|
3.34 |
1.61 |
7.01 |
0.001 |
0.33 |
0.08 |
1.36 |
0.12 |
| A |
13 |
|
|
|
|
|
|
|
|
| B |
29 |
|
|
|
|
|
|
|
|
| C |
8 |
|
|
|
|
|
|
|
|
|
Gender |
|
1.77 |
0.73 |
4.31 |
0.26 |
N/A |
|
|
|
| M |
24 |
|
|
|
|
|
|
|
|
| F |
26 |
|
|
|
|
|
|
|
|
|
Age at diagnosis |
|
0.99 |
0.92 |
1.05 |
0.773 |
N/A |
|
|
|
| 30s |
5 |
|
|
|
|
|
|
|
|
| 40s |
27 |
|
|
|
|
|
|
|
|
| 50s |
18 |
|
|
|
|
|
|
|
|
|
T stage |
|
3.04 |
1.53 |
6.03 |
0.001 |
5.22 |
1.77 |
15.44 |
0.03 |
| pT1 |
7 |
|
|
|
|
|
|
|
|
| PT2 |
7 |
|
|
|
|
|
|
|
|
| pT3 |
27 |
|
|
|
|
|
|
|
|
| pT4 |
9 |
|
|
|
|
|
|
|
|
|
N Stage |
|
2.62 |
1.54 |
4.46 |
<0.001 |
1.62 |
0.69 |
3.81 |
0.27 |
| N0 |
40 |
|
|
|
|
|
|
|
|
| N1 |
8 |
|
|
|
|
|
|
|
|
| N2 |
1 |
|
|
|
|
|
|
|
|
| N3 |
1 |
|
|
|
|
|
|
|
|
|
Differentiation |
|
1.14 |
0.37 |
3.54 |
0.83 |
N/A |
|
|
|
| Well |
5 |
|
|
|
|
|
|
|
|
| Moderate |
39 |
|
|
|
|
|
|
|
|
| Poor |
6 |
|
|
|
|
|
|
|
|
|
Histology |
|
0.49 |
0.11 |
2.11 |
0.34 |
N/A |
|
|
|
| Standard |
42 |
|
|
|
|
|
|
|
|
| Mucinous |
8 |
|
|
|
|
|
|
|
|
|
Site |
|
0.77 |
0.45 |
1.31 |
0.33 |
N/A |
|
|
|
| Rectal |
17 |
|
|
|
|
|
|
|
|
| Right side |
17 |
|
|
|
|
|
|
|
|
| Left side |
16 |
|
|
|
|
|
|
|
|
|
Budding |
|
5.76 |
2.38 |
13.8 |
0.0005 |
2.56 |
0.9 |
7.27 |
0.08 |
| High |
13 |
|
|
|
|
|
|
|
|
| Medium |
19 |
|
|
|
|
|
|
|
|
| Low |
18 |
|
|
|
|
|
|
|
|
|
LVI |
|
9.99 |
3.57 |
27.98 |
0.0001 |
6.08 |
1.17 |
31.41 |
0.03 |
| High |
13 |
|
|
|
|
|
|
|
|
| Medium |
19 |
|
|
|
|
|
|
|
|
| Low |
18 |
|
|
|
|
|
|
|
|
|
LVD |
|
5.15 |
2.04 |
12.99 |
0.00001 |
1.3 |
0.3 |
5.59 |
0.72 |
| High |
18 |
|
|
|
|
|
|
|
|
| Medium |
11 |
|
|
|
|
|
|
|
|
| Low | 21 | ||||||||
N/A indicates that the parameter was not included for multivariable analysis due to insignificance in univariate analysis. A parameter with a hazard ratio (HR) of greater than one has an adverse effect on survival and a p value of less than 0.05 was considered significant (bold type).