Table 4.
Summarizing multifactor dimensionality reduction (MDR) models for gene-gene interaction in HCV treatment outcome
| Number of factors | Best candidate models | Testing accuracy (%) | P value* | Cross-validation consistency |
|---|---|---|---|---|
| |
HCV-1 |
|
|
|
| 1 |
rs691005 |
64.3 |
0.01 |
10/10 |
| 2 |
rs691005 rs8099917 |
62.7 |
0.001 |
6/10 |
| 3 |
rs1926736 rs691005 rs8099917 |
61.3 |
0.01 |
6/10 |
| 4 |
rs1926736 rs691005 rs8099917 rs10853728 |
61.2 |
0.01 |
7/10 |
| |
HCV-2 |
|
|
|
| 1 |
rs10857328 |
58.8 |
0.2 |
6/10 |
| 2 |
rs691005 rs8099917 |
70.01 |
0.06 |
10/10 |
| 3 |
rs1926736 rs691005 rs8099917 |
58.9 |
0.6 |
9/10 |
| 4 | rs1926736 rs691005 rs8099917 rs10853728 | 49.2 | 0.96 | 10/10 |
*The P values less than 0.05 were considered significant.