FIG. 3.

GAG reduction in liver, kidney, and spleen of MPS VI mice treated with either AAV.TBG.hARSB or rhARSB. Levels of GAGs in liver, kidney, and spleen were measured in MPS VI mice treated with either AAV.TBG.hARSB (AAV.hARSB, light gray bar) or rhARSB (dark gray bar) and in normal (NR, white bar) and affected (AF, black bar) controls. Results are represented as mean±SE and the corresponding value is indicated inside each bar. Statistical comparisons were made using the one-way ANOVA and the Tukey post hoc test. The p-value vs. AF is **≤0.01. The exact p-values obtained are indicated in the Materials and Methods section. The number (n) of animals in each group is indicated inside the graph.