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. 2014 Jul 15;9(7):e101977. doi: 10.1371/journal.pone.0101977

Table 2. Distribution of Drug Pairs in Intercepted Errors.

Canceled Order Completed Order No. Errors No. Alerts Error Rate (%)a Std. Err. (%)
fluticasone fluticasone-nasal 100 4565 2.19 0.22
metoprolol metoclopramide 16 9936 0.16 0.04
nitroprusside nitroglycerin 6 19 31.6 10.7
hydralazine diphenhydramine 6 4346 0.14 0.06
propranolol propofol 5 2931 0.17 0.08
nimodipine famotidine 3 511 0.59 0.34
clonidine famotidine 3 2350 0.13 0.07
metformin metronidazole 3 6148 0.05 0.03
fluticasone-salmeterol fluticasone-nasal 2 3166 0.06 0.04
hydralazine hydromorphone 2 4346 0.05 0.03
hydralazine hydroxyzine 2 4346 0.05 0.03
methyclothiazide methylergonovine 1 1 100 0.00
minoxidil minoxidil-topical 1 48 2.08 2.06
tenofovir atenolol 1 101 0.99 0.99
metolazone metoclopramide 1 132 0.76 0.75
ibandronate ibuprofen 1 133 0.75 0.75
methyldopa methylprednisolone 1 138 0.73 0.72
Actonelb Actos 1 150 0.67 0.66
felodipine Feldene 1 177 0.57 0.56
nimodipine morphine 1 511 0.20 0.20
paroxetine pyridoxine 1 1071 0.09 0.09
tiotropium tenofovir 1 1581 0.06 0.06
nifedipine prednisone 1 2111 0.05 0.05
clonidine ranitidine 1 2350 0.04 0.04
lansoprazole alprazolam 1 2381 0.04 0.04
propranolol lansoprazole 1 2931 0.03 0.03
amlodipine amitriptyline 1 3183 0.03 0.03
amlodipine famotidine 1 3183 0.03 0.03
atorvastatin multivitamin 1 3204 0.03 0.03
hydralazine chlorzoxazone 1 4346 0.02 0.02
sertraline tetracycline 1 4529 0.02 0.02
levothyroxine levofloxacin 1 5642 0.02 0.02
hydrochlorothiazide hydrocortisone 1 6040 0.02 0.02
hydrochlorothiazide hydroxyzine 1 6040 0.02 0.02
metformin metoprolol 1 6148 0.02 0.02
metformin multivitamin 1 6148 0.02 0.02
metoprolol ketorolac 1 9936 0.01% 0.01%
metoprolol metronidazole 1 9936 0.01% 0.01%
simvastatin simethicone 1 13625 0.01% 0.01%
a

The interception rate is the number of errors (confirmed by clinician chart review) divided by the total number of alerts for that drug.

b

In this pair, at the time of the alert, the branded names were most common, >90%.