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. 2014 Jul 15;9(7):e102003. doi: 10.1371/journal.pone.0102003

Figure 6. Conditional deletion of STAT3 blocks neurotoxicant-induced GFAP up regulation.

Figure 6

Wild type (C57), Stat3 (+/+) or Stat3 (−/−) mice were administered MPTP (12.5 mg/kg, s.c.) and killed at 12 and 72 hours post dosing. Striatal GFAP and TH were measured by ELISA. All data points represent mean ± SEM, N = 5. Statistical significance was measured by two-way ANOVA with Fisher's LSD Method of post hoc analysis. Statistical significance of at least p<0.05 for the MPTP-exposed groups is denoted by * as compared to wild-type controls (C57) and by # as compared to the wild-type (C57) and Stat3+/+ groups.