Table 2.

Information used for the functional analysis and critical appraisal of each protein suggested as biomarker.

Protein name	UniprotKB AC	Gene name (STRING)	Disease and disease biomarker	Quantification (fold change)	Saliva (OralCard)	CF (OralCard)	Mucosa (OralCard)	Saliva non-PD (OralCard)	Extracellular (GO CC)	Intracellular (GO CC)	Intracellular membrane bonded (GO CC)	Secretory granule (GO CC)	Endocytic vesicle (GO CC)	Immune system process (GO BP)	Regulation of immune system process (GO BP)	Innate immune response (GO BP)	Response to bacterium (GO BP)	Response to LPS (GO BP)	Leucocyte migration (GO BP)	Regulation of cytokine production (GO BP)	Inflammatory response (GO BP)	Regulation of inflammatory response (GO BP)	Positive regulation of acute inflammatory response (GO BP)	Response to interleukin 1 (GO BP)	Enzyme inhibitor activity (GO MF)	Positive regulation of MAPK cascade (GO BP)	Jak-Stat signaling (GO BP)	Regulation of ERK1/2 cascade (GO BP)	Adaptive response (GO BP)	T cell activation (GO BP)	Osteoclastogenesis (GO BP)	Coagulation/wounding (GO BP)	Platelet activation (GO BP)	Platelet degranulation (GO BP)	Platelet-derived growth factor receptor binding (GO MF)	Angiogenic activity (GO BP)	Regulation of peptidase activity (GO MF)	Ras GTPase binding activity (GO MF)	Biomarker for other pathologies (OralCard)
C-C motif chemokine ligand 13	Q99616	CCL13	PC	4.97		+			+										+		+																		+
Thymidine phosphorylase	P19971	TYMP	PC	−3.70		+		+		+																									+	+			+
C-C motif chemokine 2	P13500	CCL2	PC	1.90	+	+								+					+																				+
Fibronectin (FN)	P02751	FN1	PC	1.84	+	+		+						+					+													+		+
Angiotensinogen (serpin A8)	P01019	AGT	PC	—		+		+	+	+										+		+				+
Clusterin	P10909	CLU	PC	—		+		+	+			+		+	+	+													+			+	+	+
Prostaglandin G/H synthase 2 (COX-2)	P35354	PTGS2	PC	0.00		+	+			+	+						+			+	+	+	+													+			+
Oncostatin-M	P13725	OSM	PC   G	726.0 128.0		+			+													+	+			+	+
C-C motif chemokine 3	P10147	CCL3	PC   PI	18.00 +	+	+															+																		+
Protein S100-A9	P06702	S100A9	PA    PC   G	−1.40 10.41 −1.75	+	+		+	+	+						+	+	+	+	+						+		+											+
Protein S100-A8	P05109	S100A8	PC   G	3.07 0.00	+	+		+	+	+							+	+																					+
Azurocidin	P20160	AZU1	PC   G	6.15 3.35		+		+		+		+					+		+	+	+																		+
Matrix metalloproteinase-9	P14780	MMP9	PC   G   PI	3.54 0.00 +	+	+		+	+								+	+						+															+
Prolactin-inducible protein	P12273	PIP	PC   G	−2.55 0.00	+	+		+						+																									+
Superoxide dismutase	P00441	SOD1	PA   PC	0.00 1.85	+	+		+						+																		+		+
Lactotransferrin	P02788	LTF	PA   PC	0.60 1.94	+	+		+			+			+			+
Peptidyl-prolyl cis-trans isomerase A	P62937	PPIA	PC   G	1.73 0.00	+	+		+						+	+				+													+		+
Apolipoprotein A-I	P02647	APOA1	PC   G	1.56 0.00		+		+							+																	+		+
Cystatin-SN	P01037	CST1	PC   G	−1.47 0.00	+	+		+																													+		+
Mucin 5B	Q9HC84	MUC5B	PC   G	1.01 0.00	+			+	+	+	+
Cystatin-S	P01036	CST4	PC   G	−0.10 0.00	+	+		+																													+
Hemoglobin subunit delta	P02042	HBD	PA   PC   G	158.2 30.87 11.00		+		+																								+							+
RANKL	O14788	TNFSF11	PA   PC   G   PI	56.99 16.09 1.32 12.89	+	+	+		+	+									+			+	+			+		+
Osteoprotegerin	O00300	TNFRSF11B	PA   PC   G   PI	−4.00 −2.28 −2.44 −0.71	+	+	+	+																							+								+
Neutrophil gelatinase-associated lipocalin	P80188	LCN2	PA   PC	18.90 1.77	+	+		+	+	+						+	+	+						+															+
Plastin-2	P13796	LCP1	PA   PC   G	15.60 4.93 0.00	+	+		+	+	+																				+									+
Neutrophil defensin 1	P59665	DEFA1	PA   PC	−14.8 4.00	+	+		+	+			+					+																						+
Serotransferrin	P02787	TF	PA   PC   G	−10.4 1.56 0.00	+	+		+		+	+		+																			+	+	+					+
Lysozyme C	P61626	LYZ	PA   PC   G	−9.10 1.99 −1.41	+	+		+	+								+				+																		+
Annexin A1	P04083	ANXA1	PA   PC   G	−8.10 1.46 −1.43	+	+		+	+	+											+	+		+	+														+
Profilin-1	P07737	PFN1	PA   PC   G	4.50 2.51 2.00	+	+		+		+	+																					+	+	+				+	+
Ig alpha-1 chain C region	P01876	IGHA1	PA   PC   G	−4.70 1.67 0.00	+	+		+																					+										+
Ig gamma-2 chain C region	P01859	IGHG2	PA   PC	3.55 1.88	+	+		+																					+										+
Ig alpha-2 chain C region	P01877	IGHA2	PA   PC	3.10 −1.19	+	+		+																					+										+
Dermcidin	P81605	DCD	PA   PC   G	−2.80 1.39 0.00		+											+																						+
Keratin, type II cytoskeletal 1	P04264	KRT1	PA   PC   G	−44.3 34.9 −1.45	+	+		+		+						+																							+
Keratin, type II cytoskeletal 2 oral	Q01546	KRT76	PA   PC   G	−6.4 5.18 −1.79		+		+		+
Complement C3	P01024	C3	PA   PC	−1.30 1.58	+	+		+	+							+					+		+		+														+
Neutrophil elastase	P08246	ELANE	PA   PC   G   PI	2.00 6.50 0.00 12.80		+		+		+		+					+	+	+	+	+	+																	+
Neutrophil collagenase	P22894	MMP8	PA   PC   PI	1.10 1.82 9.70	+	+		+	+										+																				+
Alpha-2-macroglobulin	P01023	A2M	PC   G   PI	2.15 0.00 8.10	+	+		+	+	+		+										+																	+
Alkaline phosphatase. tissue-nonspecific isozyme	P05186	ALPL	PI	5.90		+			+								+	+
Neutrophil defensin 3	P59666	DEFA3	PC   G	2.63 −2.08	+	+		+									+																						+

GO CC: gene ontology cellular component; GO BP: gene ontology biological process; GO MF: gene ontology molecular function.