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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: J Neurochem. 2008 Jul 1;106(1):231–243. doi: 10.1111/j.1471-4159.2008.05355.x

Fig. 2.

Fig. 2

Effects of prolonged local delivery of HOE-642 on striatal overflow of DA, DOPAC, and HVA. (a) Time course of striatal DA overflow (y-axis: logarithmic scale) throughout reverse microdialysis of HOE-642 (■, 3 nmol/min) for 120 min (hatched box) or continuous perfusion with aCSF (□). Inset: Total DA overflow during the periods of HOE-642 treatment (area under the curve, 100–220 min) or washout (area under the curve, 220–320 min). (b) Striatal overflow of DOPAC (●) and HVA (▼) throughout reverse microdialysis of HOE-642 for 120 min (y-axis: linear scale). All values are mean ± SEM (n = 3–5). There was a statistically significant temporal effect on levels of DA, DOPAC, and HVA associated with HOE-642 treatment (■, ●, ▼, p < 0.001 with repeated measures one-way ANOVA). *p < 0.05 relative to control group (t-test).