Skip to main content
. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: J Neurochem. 2008 Jul 1;106(1):231–243. doi: 10.1111/j.1471-4159.2008.05355.x

Table 1.

Striatal content of DA and metabolites after microdialysis delivery of HOE-642

Treated side Untreated side
DA (% of control) 65 ± 3* 100 ± 4
DOPAC (% of control) 127 ± 17 100 ± 11
HVA (% of control) 140 ± 11 100 ± 9
DOPAC/DA ratio 0.16 ± 0.04* 0.08 ± 0.02

HOE-642 was reverse dialyzed (3 nmol/min) for 2 h. Forty minutes after discontinuation of drug delivery, the mice were killed. Striata were dissected and tissue content of DA, DOPAC, and HVA were measured. Data are expressed as percent of control (untreated side) and are the mean ± SEM (n = 3). Control values (μg/g of tissue) were 14.3 ± 0.5 for DA, 1.1 ± 0.1 for DOPAC, and 0.9 ± 0.1 for HVA. The DOPAC to DA ratio was calculated for both striata in each animal.

*

Significantly different (p < 0.05) from control side. HOE-642, cariporide mesilate; DA, dopamine; DOPAC, dihydroxyphenylacetic acid.