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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biomaterials. 2014 Jun 10;35(26):7271–7285. doi: 10.1016/j.biomaterials.2014.05.036

Figure 1.

Figure 1

Structure of argatroban ((2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid). Chemically, argatroban (MW= 509) is the dipeptide between arginine and 4-methyl-2-piperidine carboxylic acid with the NH2 closest to the carbonyl group of arginine bonded to a methyltetrahydroquinoline sulfonyl group. The immobilization of argatroban was accomplished by linking the free primary amine of the arginine ‘tail’ to an isocyanate group of either HMDI or PEG-DI (red circle).