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Stepping model of DNA unwinding. The model assumes that T7 helicase separates the dsDNA in kinetically discrete steps. The number of steps (n) that a helicase needs to separate a DNA depends on the duplex length (L) and the step size (s) of the helicase. It is assumed that each step is of the same size and occurs at the same rate (k) until the helicase reaches the minimal duplex length (Lm) when the DNA separates spontaneously. The stepping model is described by Eqs. 1 and 2.
