Figure 1.

Schematic representation of the components of the CaMuZclE model to simulate calcium-driven Thr287 phosphorylation of CaMKII in skeletal muscle. The model includes calcium flow through the sarcoplasmic reticulum and sarcoplasm. Calcium is bound to the buffer calsequestrin in the SR and is transported by RyRs channel and SERCA pump between the SR and sarcoplasm. Within the sarcoplasm calcium binds to the buffers ATP and parvalbumin, mitochondria, and troponin C, initiating sarcomere shortening and force production. Furthermore, calcium binds to the calcium sensor calmodulin, which in turn activates the phosphotransferase CaMKII, initiating several pathways. A comprehensive list of all abbreviations can be found in the Appendices.