Table 1.
Relative influences of the model input parameters on the transient in phosphoThr287-CaMKII.
| Parameter | Relative influence |
|---|---|
| kbta | 0.32 |
| kPP1 | 0.24 |
| CaMax | 0.22 |
| KmPP1 | 0.20 |
| CaPump | 0.11 |
| kbi | 0.06 |
| kbtc | 0.06 |
| kTrop1 | 0.04 |
| kMitCa2 | 0.04 |
| kDye2 | 0.03 |
| kMitCa1 | 0.03 |
| kATP2 | 0.03 |
| kCaM42 | 0.03 |
| kParvCa1 | 0.03 |
| kParvCa2 | 0.03 |
| kMitMg1 | 0.03 |
| kDye1 | 0.03 |
| kATP1 | 0.03 |
| kbtb | 0.03 |
| kCSQN1 | 0.02 |
| kCaM0Boff | 0.02 |
| KdPump | 0.02 |
| kMitMg2 | 0.02 |
| kCaM20 | 0.02 |
| kTrop2 | 0.02 |
| kCSQN2 | 0.02 |
| kParvMg1 | 0.02 |
| kParvMg2 | 0.02 |
Values were calculated as described under multiparametric sensitivity analysis in Section 2.6 “Model Development” of the “Materials and Methods” section. A higher value indicates a larger influence. The most influential parameters are the speed of auto- and dephosphorylation (i.e, kbta, kPPi) and the activity of the calcium pumps (i.e, CaMax, CaPump). For abbreviations consult Tables 2 and 3.