Table 3.
Rate constants.
| Name | Value | Unit | Description | Reference |
|---|---|---|---|---|
| CaMax | 25 | [μM−1] | Ca2+ release rate | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| Power1 | 5 | [—] | RyR kinetic parameter | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| tau1 | 0.609 | [s] | RyR kinetic parameter | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| Power2 | 3 | [—] | RyR kinetic parameter | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| tau2 | 0.774 | [s] | RyR kinetic parameter | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| CaPump | 20 | [μM ∗ ms−1] | Maximum SERCA pumping | http://dare.ubvu.vu.nl/handle/1871/40249 |
| KdPump | 1 | [μM] | Dissociation constant calcium binding to SERCA | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kAtp1 | 0.054 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-ATP | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kAtp2 | 120 | [ms−1] | Off rate reaction Ca2+-ATP | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kTrop1 | 0.08 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-troponin C | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kTrop2 | 0.32 | [ms−1] | Off rate reaction Ca2+-troponin C | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kParvCa1 | 0.37 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-parvalbumin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kParvCa2 | 0.003 | [ms−1] | Off rate reaction Ca2+-parvalbumin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kParvMg1 | 1.05E − 04 | [μM−1 ∗ ms−1] | On rate reaction Mg2+-parvalbumin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kParvMg2 | 0.012 | [ms−1] | Off rate reaction Mg2+-parvalbumin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kMitCa1 | 0.37 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-mitochondria | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kMitCa2 | 0.003 | [ms−1] | Off rate reaction Ca2+-mitochondria | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kMitMg1 | 1.05E − 04 | [μM−1 ∗ ms−1] | On rate reaction Mg2+-mitochondria | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kMitMg2 | 0.012 | [ms−1] | Off rate reaction Mg2+-mitochondria | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kCsqn1 | 0.1 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-calsequestrin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kCsqn2 | 100 | [ms−1] | Off rate reaction Ca2+-calsequestrin | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kDye1 | 0.0864 | [μM−1 ∗ ms−1] | On rate reaction Ca2+-Dye | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kDye2 | 6.05 | [ms−1] | Off rate reaction Ca2+-Dye | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kCam20 | 0.01 | [ms−1] | Ca dissociation from CaM (C-terminal) | Saucerman [16] |
| kCam42 | 0.5 | [ms−1] | 2 Ca dissociation from CaM (N-terminal) | Saucerman [16] |
| kCam0Boff | 1.40E − 06 | [ms−1] | CaM dissociation from buffer | Saucerman [16] |
| kPP1 | 0.0017 | [ms−1] | Thr287 dephosphorylation | Saucerman [16] |
| KmPP1 | 11 | [µM] | Km for Thr287 dephosphorylation | Saucerman [16] |
| kbi | 0.0013 | [ms−1] | Ca4CaM dissociation from Pb | Gaertner [20] |
| kbta | 0.018 | [—] | Polynomial factor autophosphorylation | Gaertner [20] |
| kbtb | 0.015 | [—] | Polynomial factor autophosphorylation | Gaertner [20] |
| kbtc | 0.033 | [—] | Polynomial factor autophosphorylation | Gaertner [20] |
| KF50 | 8.4 | [μM] | Dissociation constant Ca-troponin C from XBn state | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| NF2 | 1.68 | [—] | Power constant for Ca-troponin C influence on kf1 | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| KF502 | 27 | [μM] | Dissociation constant Ca-troponin C from XBw state | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| NF2 | 8 | [—] | Power constant for Ca-troponin C influence on kf2 | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFm1s | 0.0045 | [ms−1] | On rate reaction XBn-XBw | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFm1 | 0.045 | [ms−1] | Off rate reaction XBn-XBw | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kF0 | 1.00E − 03 | [ms−1] | Rate second reaction XBn-XBw | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFg1 | 0.0169 | [ms−1] | Rate reaction XBs-XBr | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFg2 | 0.0337 | [ms−1] | Rate reaction XBr-XBn | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFm2 | 0.13 | [ms−1] | On rate reaction XBw-XBs | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |
| kFm2s | 1 | [ms−1] | Off rate reaction XBw-XBs | http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/ |