Table 2.
Correlation between Global DNA methylation levels and clinical and laboratory characteristic
|
DN risk factors |
Patients without diabetic nephropathy (n = 70) |
Patients with micro-albuminuria (n = 35) |
Patients with macro-albuminuria (n = 18) |
|||
|---|---|---|---|---|---|---|
| R | P-value | R | P-value | R | p-value | |
| Age-years |
0.07 |
0.55 |
0.18 |
0.31 |
-0.11 |
0.81 |
| Sex-men |
0.08 |
0.50 |
0.24 |
0.16 |
0.18 |
0.46 |
| Duration of diabetes-years |
0.37 |
0.002 |
0.12 |
0.50 |
0.06 |
0.81 |
| Age of onset-years |
-0.16 |
0.18 |
0.02 |
0.87 |
0.05 |
0.82 |
| Glycated haemoglobin-% |
0.06 |
0.59 |
0.02 |
0.91 |
0.42 |
0.08 |
| Total cholesterol-mg/dl |
-0.08 |
0.49 |
0.25 |
0.15 |
0.21 |
0.39 |
| LDL-mg/dl |
-0.05 |
0.66 |
0.20 |
0.25 |
0.26 |
0.29 |
| HDL-mg/dl |
0.02 |
0.85 |
-0.02 |
0.92 |
0.30 |
0.22 |
| TG-mg/dl |
-0.06 |
0.59 |
0.22 |
0.21 |
-0.21 |
0.39 |
| BMI-Kg/m2 |
0.09 |
0.46 |
-0.31 |
0.08 |
-0.14 |
0.17 |
| Insulin-μUI/l |
0.22 |
0.07 |
-0.07 |
0.68 |
-0.25 |
0.32 |
| FBS-mg/dl |
0.07 |
0.57 |
-0.29 |
0.09 |
0.33 |
0.17 |
| BUN-mg/dl |
-0.22 |
0.07 |
-0.02 |
0.92 |
-0.38 |
0.11 |
| Uric acid-mg/dl | 0.001 | 0.99 | 0.19 | 0.28 | -0.11 | 0.67 |