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. 2014 Jun 25;12:184. doi: 10.1186/1479-5876-12-184

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Copyright © 2014 Rosen et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of PARPi-induced DDR in cell lines shows higher induction of multiple readouts in BRCA2-/- cells compared to BRCA1+/- and BRCA1+/+cells. (A) 48 or 72 hr (columns) PARPi AZD2281 (AZD, 6 μg/mL)-induced Log₂Fold values for DDR readouts p-RPA2, p-DNA-PKcs, p21, p-ATM, and p-BRCA1 (rows) are shown for CyclinA2- or CyclinA2+ subsets (columns) of tested cell lines. Values shown are mean averages from 2 independent experiments. Cell lines are coded by HRR status (BRCA1+/+, squares; BRCA1+/-, circles; BRCA2-/-, crosses). (B) Flow plot examples of p-RPA2, p-DNA-PKcs, p-ATM induction in BRCA1+/+, BRCA1+/-, and BRCA2-/- cell lines at 48 h (Red: Unstimulated, Blue: AZD2281).